Phenytoin induced cerebellar atrophy: A case report Pratima Kumari1,*, Narayan Shivlok2, Agarwal Alka3 1Assistant Professor, Dept. of Pediatrics, Santosh Medical College, Ghaziabad, Uttar Pradesh 2Assistant Professor, Dept. of Medicine, Vardhman Mahavir Medical College, New Delhi, India 3Professor & HOD, Dept. of Pediatrics, Santosh Medical College, Ghaziabad, Uttar Pradesh *Corresponding Author: Email: pratima.sagi23@gmail.com
Online published on 27 November, 2018. Abstract The significant dose-related as well as idiosyncratic drug toxicity are encountered in pediatric practice occasionally due to the zero order pharmacokinetics and narrow therapeutic margin of phenytoin. Among uncommon side effects reported in patients with phenytoin exposure are cerebellar atrophy and at times its clinical presentation is masquerading as acute encephalitis. An unusual presentation of phenytoin toxicity in a 15-year-old girl suffering from multiple tubercular with seizure who developed bilateral cerebellar atrophy besides other features of Phenytoin toxicity over 3 years of drug use has been reported here along with possible approaches to minimize the possibility of dosing error in its prescription. Top Keywords Phenytoin, Cerebellar atrophy, Multiple tuberculoma. Top |