Immunotherapy in cancer treatment: Harnessing the power of the immune system Kumar Alok1, Singh Kanchan1, Kumar Kartik1, Kumar Sachin1, Singh Arjun2,*, Tripath Alpesh1, Tiwari Lakshya1 1Department of Pharmacology, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan305004, India 2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA19107, United States *Corresponding Author E-mail: arjunphar@gmail.com
Online Published on 26 April, 2024. Abstract Immunotherapy has revolutionized cancer treatment by leveraging the body's immune system to fight against cancer cells. This article provides an overview of immunotherapy, focusing on its different modalities, mechanisms of action, clinical applications, and the management of immune-related adverse events. Immune checkpoint inhibitors, such as PD-1 and CTLA-4 inhibitors, are prominent modalities that enhance the immune response by blocking regulatory proteins. Additionally, CAR-T therapy genetically modifies a patient's T cells to target specific proteins on cancer cells, leading to precise cancer cell elimination. Immunotherapy has demonstrated remarkable success in certain malignancies and offers new hope for patients battling cancer. Top Keywords Immunotherapy, PD-1, CTLA-4, Cancer, T cell, CAR-T therapy, Immune system. Top |