Advancing therapeutics with liposomal drug design: Harnessing the potential of liposomes for targeted drug delivery Singh Rupali1, Sharma Sachi1, Awatar Sonia1, Purva Dashain1, Singh Arjun2,* 1Department of Pharmacognosy, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan, 305004, India 2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, United States *Corresponding Author E-mail: arjunphar@gmail.com
Online Published on 26 April, 2024. Abstract Liposomal drug design has emerged as a promising approach for targeted drug delivery. This article provides an overview of the principles and strategies involved in liposomal drug design, focusing on optimizing drug stability, controlled release, and enhanced therapeutic outcomes. The composition of liposomes, including the selection of lipids, plays a crucial role in determining their properties. Size and surface modifications of liposomes enable targeted drug delivery to specific tissues or cells. Liposomes offer versatility in drug encapsulation and controlled release kinetics, improving therapeutic efficacy while minimizing side effects. Incorporating targeting ligands onto liposome surfaces enhances their affinity for diseased sites, allowing for selective drug accumulation. Stability and manufacturing considerations are vital for the successful translation of liposomal drug delivery systems. Overall, liposomal drug design holds significant potential in revolutionizing drug delivery for improved treatment outcomes. Top Keywords Liposomal drug design, Liposomes, Lipids, Drug delivery, Controlled release. Top |