Sex-based differences in the pharmacokinetic and pharmacodynamic activity of different drugs Pal Rohan1,*, Ghosh Ritam2, Acharyya Banibrata2, Saha Rajat Subhra2, Dey Sudipta2, Nandy Arpita2, Bhattacharjee Arin3 1Assistant Professor, Department of Pharmacology, Global College of Pharmaceutical Technology, Krishnanagar, Nadia, West Bengal, 741102, India 2Department of Pharmacology, Global College of Pharmaceutical Technology, Krishnanagar, Nadia, West Bengal, 741102, India 3Principal, Global College of Pharmaceutical Technology, Krishnanagar, Nadia, West Bengal, 741102, India *Corresponding Author E-mail: pal.rohan1995@gmail.com
Online Published on 30 January, 2024. Abstract The precise effects of sex on the effects of various drugs are still unknown, even though sex-specific variations in various medications are well documented. It is not uncommon for women and men to react differently to different medications due to differences in their body composition, physiology, and drug pharmacokinetics (A, D, M, E), as well as pharmacodynamics. These differences include hormonal effects during the menstrual cycle, pregnancy, and menopause. The under representation of women in clinical trials, which is a significant obstacle to the optimisation of medicines for women of all ages, directly contributes to the underuse of evidence-based medications. As an added bonus, women experience greater side effects from drugs than men do. Thus, the majority of trials that were performed on middle-aged men were used to develop current recommendations for disease prevention, diagnosis, and medical treatment. To improve the safety and effectiveness of different medications as well as to create appropriate, individualized treatment plans for both males and females, it is greatly essential to understand the sex-related differences. In order to better understand the gender-based variations in the efficacy and safety of various medicines, this review gives a brief summary of the pharmacokinetics and pharmacodynamics of many drugs, organized by gender. Top Keywords Gender differences, Sex specific differences, Gender-based pharmacology, Adverse drug reaction, Pharmacodynamics, Pharmacokinetics. Top |