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Formulation Development and Evaluation of Glibenclamide Microcapsules Using Solvent Evaporation Technique Shivhare UD1, Kale MK1, Bhusari KP1, Madankar VS1, Godbole MD2 1Sharad Pawar College of Pharmacy, Hingna Road, Wanadogri, Nagpur-440110 2Kamla Nehru College of Pharmacy, Borkhedi (Gate), Butibori, Nagpur-441108 Abstract In the present study, microcapsules containing glibenclamide were prepared by solvent evaporation method and characterized by sieve analysis and scanning electron microscopy. The microcapsules were analyzed for % encapsulation efficiency, physical properties and in-vitro release pattern. Different batches of microcapsules were prepared by altering the drug:polymer ratio. The size of microcapsules were in the range of 180–250 μm they were spherical in shape as evidenced by photo micrographs and scanning electron microscopy. The % drug entrapment was in the range of 58–83% and showed sustained drug release over a period of 12 hour. Top Keywords Microcapsules, glibenclamide, solvent evaporation. Top | |
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