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Effect of Mucuna pruriens Seed Extracts on Drug Induced Myelosuppression test using albino rats Nayak S.1,, Dixit VK2 1Bansal College of Pharmacy, Kokta, Anandnagar, Bhopal. 462021 2Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar. 470003 Abstract Seeds of Mucuna pruriens were tested for drug induced myelosuppression test using cyclophosphamide as cytotoxic drug. Ethanolic extract (50, 100 and 200mg/kg body weight, orally) its chloroform soluble fraction and insoluble fraction (50, 80 and 100 mg/kg body weight, orally) were studied on albino rats. Results of present finding suggests the ethanolic extract and its both chloroform soluble and insoluble fractions significantly (p<0.05) protect the effect of cyclophosphamide as observed by hematological studies. These investigations justifies the diversified use of Mucuna pruriens in the traditional system of medicine. Top Keywords Mucuna pruriens, Myelosuppression, Cyclophosphamide. Top | |
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