Anti-tumor and anti-oxidant activities of Pseudarthria viscida against Dalton's ascites lymphoma bearing Swiss albino mice. Vijayabaskaran M.1, Sivakumar P.1, Sambathkumar R.1, Perumal P.1, Sivakumar T.2, Jayakar B.3 1J.K.K.Nataraja College of Pharmacy, Komarapalayam, Tamilnadu, India 2Nandha College of Pharmacy, Natural Products Research Laboratory, Erode, Tamilnadu, India-638052 3Vinayaka Mission's College of Pharmacy, Sankari Main Road, Ariyanoor, (NH -47), Salem -636 308 *Corresponding Author E-mail: sivaecp@hotmail.com
Abstract The study was aimed at evaluating the anti-oxidant and anti-tumor activities of methanol extract of Pseudarthria viscida (Family: Fabaceae). The methanol extract of Pseudarthria viscida (MEPV) at the doses of 100 and 200 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of MEPV on the growth of transplantable murine tumor, life span of DAL bearing mice, hematological profile and liver biochemical parameters were estimated. Treatment with MEPV decreased the tumor volume and viable cell count thereby increasing the life span of DAL bearing mice and brought back the hematological parameter more or less normal level. The effect of MEPV decreases the level of lipid peroxidation and protein content and increased the level of Catalase (CAT) and Glutathione (GSH). The present work indicates that the methanol extract of Pseudarthria viscida roots exhibited significant anti-tumor and anti-oxidant activity in vivo. Top Keywords Pseudarthria viscida, Anti-tumor activity, Anti-oxidant activity. Top |