Hypovitaminosis D influences chronic ailments; implication for health Rajalakshimi V.1, Aanandhi M Vijey2,* 1Research Scholar, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India 2Professor and Head, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Chennai, India *Corresponding Author E-mail: hodpchemistry@velsuniv.ac.in
Online published on 24 August, 2018. Abstract In the past two decades, Vitamin D has developed a major space for research and that has transformed from the simple concept that vitamin D is important for the prevention of rickets to more physiological relevance on adults. Hypovitaminosis D being acknowledged as a pandemic, affects almost 50% of the population worldwide. The literature review recommends that the vitamin D insufficiency and its occurrence increases along with latitude, obesity, sedentary lifestyle, limited sunlight exposure and aging. A huge body of evidence revealed that subjects with vitamin D insufficiency have augmented cardiovascular disorder, abdominal obesity, insulin resistance, type 2 diabetes, hypertension and malignancies. The aim of the current review is to make an enhanced understanding of the processes by which deficits in vitamin D cause specific changes in cell and organ functions and thus augment the risk for chronic diseases of different etiology. This article also observed the frequency of vitamin D insufficiency and to assess the prospective inference for skeletal and extraskeletal health. The broad variety of disorders connected with the scarcity of vitamin D in combination with the high occurrence of these conditions signifies a unique challenge for preventive medicine. Top Keywords Chronic diseases, Vitamin D, Deficiency, Health. Top |