Potential of Anadara granosa Nanoparticles to improve the Expression of the Fibroblast Growth Factor-2 (FGF-2) in Chronic wound of Hyperglycemia conditions Budhy Theresia Indah1,*, Rahayu Retno Pudji1, Prathama Fata Ariestia2 1Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. 2Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. *Corresponding Author E-mail: theresia-i-b-s@fkg.unair.ac.id
Online Published on 06 March, 2023. Abstract Background Hyperglycemia can cause adverse effects in the oral cavity, one of which is inhibiting wound healing. Chronic hyperglycemia reduces the expression and distribution of growth factors, such as fibroblast growth factor-2 (FGF-2), a significant growth factor in angiogenesis. The disruption of wound healing may lead to chronic wounds to further infection. Routine oral wound treatment using topical steroid ointment is considered ineffective in hyperglycemic individuals due to its anti-angiogenic properties. Anadara granosa shell nanoparticles can induce the production of numerous growth factors such as FGF-2 and augment angiogenesis. Objective To determine the potential of giving Anadara granosa shell nanoparticles to increase FGF-2 in chronic inflammatory wounds with hyperglycemia conditions. Discussion Angiogenesis supports and intersects with other ongoing proliferative activities and with the remodeling phase. FGF-2 helps the proliferation of endothelial cells and the arrangement of endothelial cells to form a tube to help angiogenesis. Hyperglycemia is directly associated with a significant reduction in FGF-2-induced angiogenesis in vivo. Biogenic CaCO3 nanoparticles made from Anadara granosa have shown promising potential to increase FGF-2 by activating NF-κB signaling. Conclusion Anadara granosa shell nanoparticles have the potential to increase the expression of fibroblast growth factor-2 (FGF-2) in chronic inflammatory wounds with hyperglycemia conditions. Top Keywords Anadara granosa shell nanoparticles, Fibroblast growth factor-2, Hyperglycemia, Chronic inflammatory wounds, Wound healing. Top |