Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 3
First page : ( 1013) Last page : ( 1017)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00169

Investigating the use of liquisolid compact technique for pioglitazone HCI

Subramanian S.^*, Monisha V.

Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore - 641004, Tamil Nadu, India

^*Corresponding Author E-mail: subbu3j@gmail.com

Online published on 14 June, 2022.

Abstract

The aim of present study is to enhance the dissolution of poorly water soluble drug of Pioglitazone HCl by liquisolid compact technique. Liquisolid compact were prepared using propylene glycol as non-volatile solvent, Avicel PH102 as carrier and Aerosil 200 as coating material, sodium starch glycolate as superdisintegrant.The compatibility of excipients and drug was confirmed by FT-IR studies. The dissolution studies for prepared liquisolid tablet were distinctly higher as compared to directly compressed tablets which show significance increased in wetting properties and surface area of drug available for dissolution. The optimized PIO-7 liquisolid formulation shows acceptable flow properties, faster disintegration time and superior dissolution profile. The optimized formulation of liquisolid pioglitazone tablet shows higher drug release when compared to marketed formulation. The mechanism of drug release studied for best formulations where fitted in accordance with higuchi model and korsemeyer peppas model it is evident that a linear relationship was obtained showing that is an apparent first order process.

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Keywords

Liquisolid Compacts, Pioglitazone HCl, Dissolution, Release kinetics, Superdisintegrant.

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