Formulation and evaluation of ethosomal gel and non-ethosomal gel of S.grandiflora leaves Patekar Rohan Rajkumar1,3,*, Choudhary Heena Bholaram2,3, Rede Sachin Devidas3 1Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, Punjab, India-151401 2Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra, India- 411038 3Department of Pharmaceutical Sciences, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Chinchwad, Pune - 411019, MH- India *Corresponding Author E-mail: rohanpatekar181299@gmail.com
Online published on 14 June, 2022. Abstract The numbers of products based on new drug delivery systems have considerably increased in the past few years, and this growth is projected to carry on in the future. These bio-pharmaceuticals present challenges to drug delivery system because of their different nature and difficulty in delivery through conventional routes. Therefore, further research will focus on the delivery of these complex molecules through different routes, including nasal, pulmonary, vaginal, rectal, etc. The intend of the study was to formulate and evaluate ethosomes of Sesbania grandiflora leaves which may transport the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. Trans-dermal drug delivery is a technique which can be exploited to overcome the variables, which could affect the oral absorption of drugs such as pH, food intake and gastrointestinal motility. As compared to liposome or hydro-alcoholic solution ethosomal systems were much more capable at delivering a fluorescent probe to the skin in terms of quantity and depth. The formulations were prepared with ethanol, lecithin, propylene glycol, and glycerol and were evaluated. The lecithin (phospholipids) used as a vesicles forming component, polyglycol and ethanol used as a skin penetration enhancer. The drug released of formulated ethosomal gel was 4–5 times improved as compared to non ethosomal gel which directly achieves unparalleled flexibility in formulation. Ethosomal gel successfully addresses the issues relating to the drug delivery of poorly water-soluble drugs, peptides, potent drugs and the release of multi-drugs. Top Keywords Sesbania grandiflora, Ethosomes, Bioavailability, Transdermal, Ethosomal-gel, Nano-carrier, Novel drug delivery, Diffusion. Top |