Research Journal of Pharmacy and Technology
Year : 2022, Volume : 15, Issue : 3
First page : ( 1090) Last page : ( 1096)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.52711/0974-360X.2022.00182

Plant Calotropis gigantea: Management of diabetic nephropathy in experimentally induced diabetes in rats

Kumar Harish^*, Sharma Sunil, Vasudeva Neeru

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India-125001

^*Corresponding Author E-mail: harishbishnoi88@yahoo.com

Online published on 14 June, 2022.

Abstract

The research study designed to investigate the nephroprotective efficiency of Calotropis gigantea stem bark extract. Streptozotocin (60 mg/kg/i.p) diabetes model was used to evaluate the Nephropathy potential of Calotropis gigantea in animals. After single administration of STZ nephropathic complication develops within four weeks. Nephropathy was assessed by blood urea nitrogen, increasing serum creatinine level, microproteinuria, lipid alteration and high renal oxidative stress. Calotropis gigantea stem bark extract shows prominent nephroprotective effect at high dose (500 mg/kg p.o) as compared to low dose treatment (200 mg/kg p.o) in experimentally induced diabetic nephropathy in rats. The present study indicated the plant having of medicinally significant bioactive constituents that shows tremendous nephroprotective effect. It is concluded that stem bark extract of Calotropis gigantea had a role in diabetes control and impedes the continuation of diabetes-induced experimental nephropathy.

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Keywords

Calotropis gigantea, Diabetes mellitus, Nephropathy, Microalbuminuria.

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