Effect of zinc as an add-on to metformin therapy on glycemic control, serum insulin, and c-peptide levels and insulin resistance in type 2 diabetes mellitus patient Younis Hend Y.1, Thanoon Imad A.2, Fadhil Nabeel N.3, Merkhan Marwan M.4,* 1Alssalam Teaching Hospital, Ninevah Health Directorate, Mosul, Iraq 2College of Medicine, University of Mosul, Mosul, Iraq 3College of Medicine, Ninevah University, Mosul, Iraq 4College of Pharmacy, Ninevah University, Mosul, Iraq *Corresponding Author E-mail: marwanmerkhan@uomosul.edu.iq
Online published on 14 June, 2022. Abstract Type 2 diabetes mellitus (T2DM) is an insidious disorder that may progress asymptomatically, leading to secondary complications. Diabetics were found to have a significantly lower zinc level. This study aims to assess the effects of zinc supplementation for eight weeks on glycemic control, serum insulin level, serum C-peptide level, and insulin resistance. Zinc plus metformin using group had a significant decrease in fasting blood glucose level and glycated hemoglobin, as well as a significant increase in serum insulin and C-peptide levels, but no effect on insulin resistance compared to zinc-free metformin group. Comparing the two groups at the end of the study, the combined effect of zinc plus metformin was highly important versus metformin only except for C-peptide and insulin resistance. Zinc levels were significantly elevated and returned to normal in the interventional group, while in the control group, levels were rather decreased. Top Keywords Glycemic, Insulin, Metformin, Zinc, Diabetes. Top |