The hypoglycemic and hypolipidemic effect of 5- naphthalidin-2, 4 thiazolidinedione derivatives in alloxan induced type ii diabetic model Rekha S.1,*, Divekar Kalpana2, Chandrashekhara S.3 1Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India 2Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, Karnataka, India 3Department of Pharmaceutics, Dr. Ravi Patil College of Pharmacy, Belgaum, Karnataka, India *Corresponding Author E-mail: rekha.maheshh@gmail.com
Online Published on 08 June, 2022. Abstract Objective The present study was undertaken to study antidiabetic and antihyperlipidemic potentials of 5-naphthalidin-2, 4-thiazolidinediones derivatives and its interaction with rosiglitazone in alloxan-induced diabetic rats. Methods Diabetes was induced in male swiss albino rats by single intramuscular injection of alloxan (0.15 mg/Kg i.m) and NIDDM-rats received 4b, 4c or 4d (36 mg/Kg, p.o). Fasting blood glucose (FBG) levels were measured by glucose-oxidase & peroxidase reactive strips. Serum biochemical parameters such as total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) cholesterol were estimated. The statistical analysis of results was carried out using Student t-test and one-way analysis (ANOVA) followed by Duncan's Multiple Range Test (DMRT). Results The results revealed that 4b, 4c and 4d showed promising results by lowering the blood glucose. Moreover, 4c compound displayed high efficiency for lowering lipid profiles compared to others. Conclusion These results suggest that taking 5- naphthalidin-2, 4 TZD orally twice/day is a valuable treatment for Non insulin dependent diabetes mellitus (NIDDM) and hypolipidemic agent. They exert their effects through altering regulation genes in glucose and lipid metabolisms in diabetic rats. Top Keywords Diabetes, Free radical scavenging activity, RIN-5F cells, Diseased human lung fibroblast. Top |