Radical scavenger and anti-diabetic potencies of Etlingera elatior fruits growing in South East Sulawesi-Indonesia Imran1, Wahyuni2, Fristiohady Adryan2, Leorita Mesi2, Malaka M. Hajrul2, Ilyas Y Muhammad2,3, Musadar4, Rahmatika Nur Syifa5, Darmawan Ahmad6, Fajriah Sofa6, Yodha Agung W. Mahatva2, Sahidin I2,* 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Halu Oleo, Kendari, 93232, Southeast Sulawesi, Indonesia 2Faculty of Pharmacy, Universitas Halu Oleo, Kendari, 93232, Southeast Sulawesi, Indonesia 3Program Study of DIII Health Analyst, Polytechnic Bina Husada, Kendari, 93232, Southeast Sulawesi, Indonesia 4Faculty of Agriculture, Universitas Halu Oleo, Kendari, 93232, Southeast Sulawesi, Indonesia 5Faculty of Medicine, Universitas Halu Oleo, Kendari, 93232, Southeast Sulawesi, Indonesia 6Research Centre for Pharmaceutical Ingridient and Traditional Medicine, National Research and Innovation Agency (BRIN), Kawasan Puspitek, Tangerang Selatan, Banten, Indonesia *Corresponding Author E-mail: sahidin02@uho.ac.id
Online published on 20 February, 2023. Abstract Etlingera elatior have many biological properties. Thus, we aim to isolate and to evaluate radical scavenger potency of compounds from Etlingera elatior fruits and antidiabetic potency of the ethanol fruits extract. E. elatior fruits were collected from the Wolasi Forest, South East Sulawesi. The isolation was carried out by using chromatography technique and the compound structures were evaluated by interpreting spectroscopic data (FTIR, 1H and 13C NMR). The radical scavenger activity was evaluated towards DPPH (1,1-diphenyl 2-picryl-hydrazyl) radicals. Antidiabetic activity was carried out in experimental animals, as well as the histopathology of pancreatic organ. Four aromatic compounds have been isolated and identified, quercetin (1) as flavonoid, firstly reported from E.elatior fruits, p-coumaric acid (2), vanilic acid (3), and p-hydroxybenzoic acid (4). Radical scavenger potency of quercetin> vanilic acid>p-hydroxybenzoic acid>p-coumaric acid> the extract. Ethanol extract of Wualae fruits showed activity as antidiabetic and protective effect to beta cell at concentration 200; 300; and 400mg/kgBw, with most effective in decreasing plasma glucose and protecting beta cell was 400 mg/KgBw. E.elatior fruits possess pronounced radical scavenger and anti-diabetic properties which may be due to the presence quercetin in the plant. Therefore, the fruit’s extract can be further developed for the cosmetics and diabetic management. Top Keywords Etlingera elatior, Fruits, Radical scavenger, Anti-diabetic, Histopathology. Top |