Preparation and FTIR-ATR combined with chemometrics analysis of self-emulsifying loaded sungkai extract from Peronema canecens Shiyan Shaum1,2,*, Ramadona Nafisah1, Utami Widea Fitri1,2, Depriyanti Natascha1,2, Mukafi Anazir1, Noviandhani Wanda1,2 1Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Indralaya (OI)Sumatera Selatan, 30662, Indonesia 2Phytopharmaceutical Reseach Center (PRC) at Laboratory of Pharmaceutical Biology, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Indralaya (OI), Sumatera Selatan, 30662, Indonesia *Corresponding Author E-mail: shaumshiyan@unsri.ac.id
Online Published on 10 October, 2023. Abstract The use of immunomodulators is one strategy in maintaining the immune system during the Covid-19 pandemic. Sungkai leaf extract from Peronema canecens keeps the immune system in good shape. Therefore, in this study, we formulated a self-emulsifying loaded sungkai leaves extract (SE-SLE) with oleic acid and virgin coconut oil (VCO) oil phases, span 80 and tween 80 as surfactants and co-surfactants in the form of PEG-400 and PG. Chemometric analysis was conducted by observing the typical pattern in each FTIR-ATR spectra. The pattern is divided into several groups based on the wavenumber and analyzed using principal component analysis (PCA) to identify the compounds contained therein. Grouping based on chemical properties via IR spectra on SE-SLE resulted in two large groups. The results obtained are beneficial as initial information in developing and optimizing the self-nano emulsifying drug delivery system formula. Top Keywords Chemometrics, FTIR-ATR, Peronema canecens, Self-emulsifying, Emulsion, Sungkai, Principal component analysis, Cluster analysis. Top |