Antibacterial effect of lignin polymer on multidrug resistant bacteria identified by vitek system Hussein Safaa Hadi1, Al-Mugdadi Suhad Faisal Hatem2, Mjali Lec Ali Jalil3, Latef Qabas Nather2, Okhti Zahraa Ahmed2,* 1Teaching Laboratories, Medical City, Baghdad, Iraq 2Department of Clinical Laboratories Sciences, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq 3Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq *Corresponding Author E-mail: zahraaahmedokhti1981@gmail.com
Online Published on 10 October, 2023. Abstract Background Widespread usage of antimicrobial drugs has increased the emergence of antibiotic-resistant pathogens and that's why we need new drugs. Lignin and its derivatives considered as an antioxidant, anti-inflammatory, insecticidal and antimicrobial. This study aimed to investigate the effect of lignin polymer against the bacteria isolated from clinical samples, and to study the antibiotic resistance pattern using the Vitek system. Materials and Methods 50 clinical bacterial samples were collected from two hospitals in Baghdad city. All the isolates of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were subjected to Vitek system to determine the resistance for 12 antibiotics. The Soda lignin polymer had been prepared from the palm tree empty fruit/ Malaysia. The biological activity of lignin polymer against resistant bacteria was evaluated by well agar diffusion method. Results According to the Vitek system, all the bacterial isolates were multi-resistance to many antibiotics. Lignin polymer dilutions inhibited the growth of some bacterial isolates, and it was more effective in all the concentrations with a good inhibition zone on Pseudomonas aeruginosa which reached to 20mm. Conclusion Lignin polymer has an antibacterial effect against some pathogenic multidrug resistant bacteria isolated from clinical samples, including urine and wound infection. Lignin polymer was more effective in all the concentrations on the isolates of Pseudomonas aeruginosa, with a good inhibition zone. Top Keywords Lignin polymer, Antibacterial, Multidrug resistant bacteria. Top |