The potential of Lactobacillus casei on TNF-α and IL-1β levels type 2 diabetes mellitus Rahayu Retno Pudji1,*, Sumaryono Bambang1, Sandi Nadia Farikha2 1Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia 2Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia *Corresponding Author E-mail: a-retno-p-r@fkg.unair.ac.id
Online Published on 10 October, 2023. Abstract Type 2 diabetes mellitus is a disease caused by insulin resistance which will cause blood glucose levels to increase. That factor can result in an increase of proinflammatory cytokines such as TNF-α dan IL-1β which will cause the severity of the disease gets worse. Intraoral antidiabetic drugs have several side effects; therefore, it is necessary to provide probiotic supplements such as Lactobacillus casei to reduce levels of TNF-α dan IL-1β so that type 2 diabetes mellitus doesn’t get worse. These bacteria can also increase levels of anti-inflammatory cytokines such as IL-10. This study aims to learn and understand more deeply about the potential of Lactobacillus casei on TNF-α and IL-1β levels in type 2 diabetes mellitus. Diabetes mellitus type 2 is a chronic disease by the pancreas not being able to produce the hormone insulin in large quantities due to insulin resistance caused by impaired insulin secretion in pancreas. TNF-α and IL-1β is a cytokines that plays role in the body’s defense function, if cytokines produce in excess amount it will increase the inflammatory process. Lactobacillus casei is a probiotic bacterium that can be found in yoghurt, cheese, raw meat, and other food ingredients. Lactobacillus casei has the potential to reduce TNF-α dan IL-1β levels in type 2 diabetes mellitus. Top Keywords Lactobacillus casei, TNF-α, IL-1β, Type 2 diabetes mellitus, Diabetes. Top |