Gastro retentive drug delivery system: Latest approach towards novel drug delivery Sawanny Rajni1, Sharma Archana1, Jain Shashank2, Mukherjee Swarupananda3,*, Khamkat Piyali4 1Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, Knowledge Park - II, Institutional Area, Greater Noida, Uttar Pradesh - 201306, India 2Ram-Eesh Institute of Vocational and Technical Education, Plot No. 03, Knowledge Park-I, Greater Noida, Uttar Pradesh - 201306, India 3NSHM Knowledge Campus, Kolkata - Group of Institutions, Department of Pharmaceutical Technology, 124, B.L Saha Road, Kolkata, 700053 4Department of Pharmaceutical Technology, Brainware University, 398, Ramkrishnapur Road, Barasat, Kolkata - India *Corresponding Author E-mail: swarup_mukherjee@rediffmail.com, swarupananda.mukherjee@nshm.com
Online Published on 10 October, 2023. Abstract Numerous attempts were improved to access the bioavailability and clinical output of oral dosage forms. Different types of gastro retentive drug delivery systems (GRDDS) was developed to enhance the therapeutic efficacy of medications which are unstable at alkaline pH, results a narrow absorption window with active locally in the stomach, and gets easily solubilized in acidic conditions. So the physiological condition of the stomach and the different elements that influence GRDDS will be discussed. In general, this review will illuminate and direct detailing researchers in planning, formulation, and designing the GRDDS. Top Keywords Gastroretentive drug delivery systems, Gastric retention time, GI absorption window, Polymer gastric retention time, Bioadhesive, Bioavailability. Top |