Phytochemical screening, antimicrobial potential, ADME predictions targeting the Helicteres isora L. fruit extracts and their essential oil Sharma Pooja*, Bithel Navneet** Department of Botany and Microbiology, Gurukula Kangri (Deemed to be University), Haridwar, (249404) Uttarakhand, India *Corresponding Author E-mail: pooja.sh1611@gmail.com
**navneetbithel@gmail.com
Online Published on 5 February, 2024. Abstract The essential oil of this plant was excluded and identified by the Gas chromatography technique. Identification outcome showed the existence of different antimicrobial compounds in the essential oil of Helicteres isora such as 6,10,14-Trimethylpentadecan-2(1), n-Hexadecanoic acid (2), phytol(3a) and isomenthol(3b) which is eminent for its antibacterial attribute and pharmacokinetic studies. H. isora exhibited antimicrobial activity due to the existence of effectual molecules. Qualitative assessment of different phytochemicals of H. isora such as alkaloids, flavonoids, carbohydrates, saponins, tannins, steroids, terpenoids, and cardiac glycosides was executed. Compounds 1 and 3 both showed the highest absorption rate (~100%). All compounds obey to Lipinski rule indicated that all compounds have good drug likeness properties and good bioavailability. The antimicrobial activity of H. isora was tested by agar well diffusion method against five different pathogens such as Staphlococcus aureus, Streptococcus pyogens, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa respectively. Different outcomes are exhibited by phytochemicals and antimicrobial activities. The methanol extract of this plant showed a maximum zone of inhibition as compared to other extracts of H. isora. The lowest concentration of H. isora was found to be 3.12mg/ml, respectively. Similar, essential oil of H.isora exhibited the largest zone of inhibition against Escherichia coli due to eminent antibacterial attributes. Top Keywords Helicteres isora L., Antimicrobial activity, Phytochemical analysis, Methanol, Pharmacokinetics. Top |