Antibacterial activity of Rosa damascene petals mill extracts Kaddar Rafah1,*, Hasan Nouma1, Al-Diab Dima2 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tishreen University, Latakia, Syria 2Department of Analytical and Food Chemistry, Faculty of Pharmacy, Tishreen University, Latakia, Syria *Corresponding Author E-mail: rafahkaddar12345@gmail.com
Online Published on 5 February, 2024. Abstract Infectious diseases are one of the major common problems facing the world. Staphylococcus aureus and Escherichia coli are two causes of infectious diseases and are considered as multi drug resistance pathogens. There is a continuing need for the discovery of new agents to overcome antibiotic resistance. Plants used in traditional medicine comprise several components which can serve as alternative candidates. Of these components, phenolic compounds, a secondary plant metabolite, account for antibacterial activity of many plants. Rosa damascena, traditionally used for its several therapeutic properties, is highly rich of phenolic compounds. In this in vitro study, aqueous and ethanolic extracts of the Rosa damascene petals mill were prepared and the phenolic content was determined. The extracts were tested for antibacterial activity using the disk diffusion method and the broth microdilution method for MIC determination. The extracts were able to inhibit the growth of studying pathogens. Staphylococcus aureus was more sensitive to Rosa damascena aqueous extract with a MIC of 0.28×103μg/ml and inhibitory zone of 17.33±0.85mm. On the contrary, Escherichia coli was more sensitive to Rosa damascene ethanolic extract with a MIC of 0.2×103μg/ml and inhibitory zone of 16.33±1.15mm. The results suggest the antibacterial activity of the Rosa damascena mill. Top Keywords Antibacterial activity, Escherichia coli, Phenolic Compounds, Rosa damascene extract, Staphylococcus aureus. Top |