Antiviral activity and hepatoprotection of Hylocereuspolyrhizus peel extract Wahdaningsih Sri1,2, Rizkifani Shoma1,*, Untari Eka Kartika1, Yap Intan1, Agustriangga Muhammad Rafly1, Asmara Amrina Rasyada1, Huda Alfian Nur1 1Pharmacy Department of Medicine Faculty, Tanjungpura University, Jalan Hadari Nawawi, Pontianak, 78124, West Kalimantan, Indonesia 2Tropical Herbal Center of Science and Technology, Tanjungpura University, Pontianak, 78124, Kalimantan Barat, Indonesia *Corresponding Author E-mail: shomarizki@pharm.untan.ac.id
Online Published on 5 February, 2024. Abstract Degenerative diseases of the liver cause cirrhosis and liver cancer morbidity and lead to death. Efforts to prevent a person’s condition with disorders of the liver through antiviral and hepatoprotective agents are necessary to suppress the progression of liver disease through materials that have the potential as anti-degenerative. Dragon fruit extract which is one of the tropical fruits included in the Cactaceae tribe; can increase phagocytosis, the number of cells, and the total number of leukocytes and affect the relative weight of the spleen. Currently, there has been no scientific publication on the antihepatitic activity of red dragon fruit peel (Hylocereuspolyrhizus) and prototype preparation products for standardized herbs. The long-term goal of the research is to determine the anti-degenerative potential of red dragon fruit peel extract through its hepatoprotective and antiviral properties, safety, and standardization of the extract into a standardized herbal medicine. The research method was The Randomize Posttest-only Control Group Design using 25 male rats which were divided into 5 groups. The outcome recognized a good hepatoprotection activity from red dragon fruit peel extract (Hylocereuspolyrhizus) as indicated by decreased levels of SGPT and SGOT, and histopathological observation, but rather weak activity on HCV (Hepatitis C Virus). Based on the results of reading the SGPT and SGOT analysis data, it can be concluded that the effective dose to provide a hepatoprotective effect is a dose of 200 mg/kg body weight. Top Keywords Anti-degenerative, Hepatitis C, Hepatoprotector, Red Dragon Fruit Peel, Antiviral Compound. Top |