Effect of ethanol extract of sala (Cynometra ramiflora Linn.) leaves for reducing blood glucose levels in male wistar rats induced by alloxan Haryoto*, Humairah**, Sujono Tanti Azizah***, Muhtadi****, Suhendi Andi***** Universitas Muhammadiyah, Surakarta, Central Java, Indonesia *Corresponding Author E-mail: haryoto@ums.ac.id
***tanti.azizah@ums.ac.id
****muhtadi@ums.ac.id
**humairah@ums.ac.id
*****andi.suhendi@ums.ac.id
Online Published on 5 February, 2024. Abstract Diabetes is a chronic illness brought on by either insufficient insulin production by the pancreas or inefficient insulin utilisation by the body. There is currently no proven diabetes treatment. The development of current therapies is solely focused on preserving and enhancing patients' quality of life. In addition to utilising oral hypoglycemic medications or insulin injections to control blood sugar, several medicinal plants have also undergone pharmacological testing and can be used experimentally. There were 5groups, namely negative control group (0.5% Na CMC), positive control (glibenclamide 0.9mg/kg), ethanol extract of Sala leaves at doses of 250, 500, and 1000mg/kgBW. Each group was induced by alloxan 150mg/kg intraperitoneal body weight before fasting blood glucose levels 200mg/dL. Each group's blood glucose levels were taken and checked as pre alloxan, post alloxan, 7 and 10 days after treatment. The results showed that the ethanol extract of Sala leaves with doses of 250, 500, and 1000mg/kg for 7 and 10 days after treatment showed glucose-lowering activity (p<0.05) on all alloxan induction. The ethanolic extract of the leaves of the Sala plant (Cynometra ramiflora Linn.) with doses of 250, 500, and 1000mg/kgBW for 7 and 10 days showed significant glucose-lowering activity (p<0 0.05) in alloxan-induced mice. Top Keywords Alloxan, Blood glucose, Cynometra ramiflora Linn. Wister rats, Sala plant. Top |