Validated photodiode array based stability indicating RP-HPLC method for simultaneous estimation of cinnarizine and domperidone maleate in tablet dosage form Patel Ashok B.1,*, Gol Akshat M.2,**, Akhiyaniya Sonal M.2,***, Vyas Amitkumar J.2,****, Patel Ajay I.2,*****, Dudhrejiya Ashvin V.2,****** 1Government Pharmacy College, Gandhinagar, Gujarat, India, Postal Code: 382027 2B.K. Mody Government Pharmacy College, Polytechnic Campus, Near Aji Dam, Rajkot, Gujarat, India, Postal Code: 360003 *Corresponding Author E-mail: abp2038@gmail.com
**akshatgol95@gmail.com
***sonalakhiyaniya277@gmail.com
****amitvyas77@gmail.com
*****aipvk84@gmail.com
******ashvinvd@gmail.com
Online Published on 5 February, 2024. Abstract For the simultaneous measurement of Cinnarizine and Domperidone Maleate in bulk and tablet dosage form, a accurate, reliable, robust, and cost-effective RP-HPLC method is developed. Chromatographic separation was accomplished using a mobile phase of Acetonitrile: 10mM Potassium dihydrogen phosphate (pH 3.0) (70:30% v/v) in an isocratic elution mode at a flow rate of 1mL/min on a Neuclosil C18 (25cm×4.6mm, 5μm) column at a wavelength of 271nm. Acidic, basic, oxidative, thermal, and photolytic stress environments were used to degrade the drugs. Cinnarizine and Domperidone Maleate were found to have linearities of 8-48μg/mL and 7.6-45.6 μg/mL, respectively. For both medicines, a % recovery of 99-101 was discovered. This method was validated as per ICH (Q2R1) guideline. Top Keywords Cinnarizine, Domperidone Maleate, Force Degradation Study, Calcium Channel Blocker, ICH guideline (Q2R1). Top |