Protective effect of galantamine on attenuating cisplatin-induced neurotoxicity: An In-vitro and In-vivo approach Sahu Vikram Kumar1,*, Hariyadi Dewi Melani2, Dash Sribatsa Lanchhana3, Sharma Nitin4, Karwasra Ritu5 1Pharmaceutics DepartmentMaharana Pratap College of Pharmacy, Kanpur, India, 209217 2Pharmaceutics Department Faculty of Pharmacy, Universitas Airlangga, Indonesia, 60115 3Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar - 751004, Odisha, India 4Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Sector - 125, Noida, 201313, India 5Central Council for Research in Unani Medicine, Ministry of AYUSH, Janakpuri, New Delhi, 110058, India *Corresponding Author E-mail: vikramsahuknp@gmail.com
Online Published on 5 February, 2024. Abstract Galantamine is a drug of choice for the treatment of Alzheimer's disease and possesses antioxidant, anti-inflammatory and cholinomimetic as non-FDA-approved indications. This study designed to explore the impact of Galantamine to attenuate cisplatin-induced neurotoxicity and oxidative stress. Experimental animals were segregated into five groups viz-a-viz group I as normal control, II as cisplatin control, and III-V as galantamine at varying doses, low (2.5mg/kg), medium (5mg/kg) and higher (10mg/kg). All the samples were orally administered, daily for 14 days. Cisplatin was injected intraperitoneally on day 8 to all groups except normal control. Assessment of neurotoxicity was done by measurement of a balance of antioxidant (GSH, SOD) and pro-oxidant (MDA), histopathological investigations. Dose-dependent significant (p<0.05) reduction in neurotoxicityhas been found by galantamine with reduction (p<0.01) in oxidant stress markers. Pronouncedreduction in apoptosis and elevation of disturbed hematological, and biochemical alterations were also observed with significance of p<0.001 in galantamine groups. We have observed that galantaminedose-dependentlyattenuates neurotoxicity, and oxidative stress, reversed the histopathological alterations and inhibits activated pro-inflammatory mediators (TNF-α). The research work provides drug repurposing of galantamine and providespreliminary ground for the treatment and management of cisplatin-induced neurotoxicity towards the clinical domain. Top Keywords Oxidative stress, Galantanime, Apoptosis, Neurotoxicity, Histopathology. Top |