Preparation of new flubendazole microparticules using sodium alginate, caroboxymethyl strach and ascorbic acid for the colonic delivery Mokhnache Kamel1,2,*, Bouchakour Fayza3, Kellil Hadia4, Madani Salim2, Chaouche Siham Frah1, Beloraj Fatima Zohra1, Charef Noureddine2 1Department of Process Engineering, University Hassiba Benbouali, Chlef, Algeria 2Laboratory of Applied Biochemistry, University Ferhat Abbas, Setif, 19000, Algeria 3Laboratory of Molecular Biology, Genomics and Bioinformatics, University Hassiba Benbouali, Chlef, Algeria 4Faculty of Nature and Life Sciences, University Abbes Laghrour, Khenchela, Algeria *Corresponding Author E-mail: kamelmokhnache@yahoo.com
Online Published on 5 February, 2024. Abstract Diseases related to intestinal parasites require repeated administration of antihelminthic drugs throughout one's lifetime, using various routes, including oral administration. This mode of administration can pose a problem with treatment adherence for the patient. In order to overcome these difficulties, we have considered the development of new matrices: modified starch, which could facilitate the development of an oral therapeutic system (microparticules) with controlled colonic release. As the active ingredient, we used flubendazole (100 mg) in different prepared excipients: modified starch and sodium alginate, combined with other active substances; ascorbic acid and phloroglucinol as adjuvants to enhance the efficacy of flubendazole. These formulations were prepared in the form of microparticules. The study of flubendazole release in buffer solutions at pH 1.2 and pH 6.8 showed continuous release profiles. Chemically modified starch matrices using sodium monochloroacetate are suitable for the development of a controlled release system for antihelminthic drugs. The results confirm the colonic release, with an excellent enhancement when using ascorbic acid. Top Keywords Parasites, Flubendazole, Modified Starch, Microparticule, Prolonged Release. Top |