In vitro anticancer activity of Rumex abyssinicus root extracts on breast cancer MCF-7 cell lines Tesfay Trhas1, Tekluu Berihu1, Chaithanya Krishna K1, Varma Dhanunjaya Lakkamraju2,3, Palleti John Dogulas3, Rai Sudhish4, Kamalakararao K5,* 1Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Tigray Region, Ethiopia 2Department of Human Genetics, Andhra University, Visakhapatnam, A.P, India - 530003 3Research and Development, Centre for Computational and Biological Sciences (CCBS), 48-12-16, Srinagar, Near RTC complex, Visakhapatnam - 530016, Andhra Pradesh, India 4Department of Pharmacognosy, Tagore Institute of Pharmacy and Research, Bilaspur, Chhattisgarh, India 5Department of Biochemistry, University College of Science and Technology, Adikavi Nannaya University, Rajamahendravaram, Andhra Pradesh, India *Corresponding Author E-mail: kamalakar.kkr@gmail.com
Online Published on 5 February, 2024. Abstract Breast cancer is the leading cause of death in women. Currently existing chemopreventive and chemotherapeutic drugs promote resistance to breast treatment, and long-term usage results in unwanted side effects. Plant-derived anticancer agents have various advantages over chemical chemotherapeutic therapies, including lower cytotoxicity and higher pharmacological efficacy. Rumex abyssinicus (R. abyssinicus) has long been used as a traditional medicinal plant in Ethiopia for the treatment of infectious and non-infectious diseases. The purpose of this study is to evaluate the phytochemical analysis and investigate the in vitro cytotoxicity effect in MCF-7 breast cancer cell lines. R. abyssinicus dried roots powder was extracted with soxhlet from low polar to high polar solvents. Using established techniques, phytochemical screening of organic roots extracts of R. abyssinicus was performed. In vitro anticancer activities were evaluated by MTT assay. Among the organic root extracts of R. abyssinicus evaluated againstMCF-7 breast cancer cell lines, the chloroform extract displayed substantial in vitro cytotoxicity with an IC 50 value of 175.82g/ml. As a result, the researcher concluded that the chloroform extract of R. abyssinicus shown potential in vitro cytotoxicity in MCF-7 breast cancer cell lines. Top Keywords Rumex abyssinicus, Anticancer, Apoptosis, MCF-7 cell lines, MTT assay. Top |