Potential of bidara leaf as adjunctive therapy against breast cancer cell line: A review Yansen Ifuling Audrein1, Theresia Indah Budhy2,3, Alexander Patera Nugraha2,4,5,*, Joestandari Florentina6, Noor Tengku Natasha Eleena Binti Tengku Ahmad7,8 1Graduate Student of Immunology, Post Graduate School, Universitas Airlangga, Surabaya, 60115, Indonesia 2Immunology Study Program, Postgraduate School, Universitas Airlangga, Surabaya, 60115, Indonesia 3Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia 4Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60115, Indonesia 5Graduate Student of Dental Health Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia 6Faculty of Dentistry, Institute of Health Bhakti Wiyata, Kediri, Indonesia 7Membership of Faculty of Dental Surgery, Royal Collage of Surgeon, Edinburgh University, United Kingdom 8Malaysian Armed Forces Dental Officer, 609 Armed Forces Dental Clinic, Kem Semenggo, Kuching, Sarawak, Malaysia *Corresponding Author E-mail: alexander.patera.nugraha@fkg.unair.ac.id
Online Published on 5 February, 2024. Abstract Background Breast cancer or Carcinoma mammae is a malignancy that damage the gland ducts, and breast supporting tissues. Breast cancer is ranked first as a malignancy that often occurs in the world. The majority of women with breast cancer will have many surgeries. Chemotherapy is frequently used in conjunction with surgery. However, the side effects of chemotherapy drugs can damage healthy cells. Bidara leaf are one of the most promising sources of bioactive compounds for the pharmaceutical field in the treatment of breast cancer. Aims This review article aims to describe the several types of Bidara leaf that contain compounds and anticancer activity that have potential as alternative treatments for breast cancer through narrative review. Review This review article discusses several types of Bidara leaf and their anticancer activity. Conclusion From the results of a journal review, it was found that several types of Bidara leaf with breast anticancer activity were Ziziphus spina christi, Zizyphus mauritiana, Ziziphus nummularia, with various activities such as cytotoxicity, antiproliferative, proapoptotic, and proinflammatory on the MCF-7 breast cancer cell line. Top Keywords Cancer, Bidara leaf, Medicine, Cytotoxic, Non-communicable disease. Top |