Effect of platelet rich plasma in regenerative endodontic treatment: A review of clinical trials Rezazadeh Hojat1, Okhovatfard Mehrnaz2,* 1Student, Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran 2Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran *Corresponding Author E-mail: hojatrezazadeh777@gmail.com
Online Published on 5 February, 2024. Abstract Endodontic treatments are emerging solutions using biological materials in the field of reconstructive dentistry. Platelet-rich plasma (PRP) with numerous properties in the repair of body tissues has attracted the attention of many researchers. Hence, this systematic review study was carried out to evaluate the effect of PRP in regenerative endodontic treatment. The present systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. Until April 2023, PubMed/Medline, Web of Science, Scopus, and Google Scholar databases were searched using the relevant keywords including “Platelet Rich Plasma”, “Plasma, Platelet-Rich”, “Regenerative Endodontic”, “Endodontic, Regenerative”, and “Endodontics, Regenerative”. Of 186 identified records through database searching, 5 randomized controlled trials (RCTs) were included in this systematic review. The sample size in RCTs varied between 53 and 338. The range of subject’s age was from 13 to 67. Overall, the evidence of this review revealed that PRP plays an important role in healing of teeth with endodontic problems through regeneration of their soft and hard tissues. Overall, PRP seems to be effective in regeneration and healing of damaged dental tissues. However, further high quality assessments are required for demonstrating therapeutic role of PRP in regenerative endodontic. Top Keywords Platelet Rich Plasma, Regenerative Dentistry, Regenerative Endodontic, Scaffold. Top |