The Influence of the coating on the release of Ibuprofen from the Tablet: Comparative Dissolution Study of the different types of coating Bennani Ismail1,2, Chefchaouni Ali Cherif3,4,*, Benhaddou Hajar3, Alami Madiha Chentoufi5, Moukafih Badreddine1,2, Marrakchi Soufiane El1,2, Fahry Aicha3, Alaoui Yassir El3,4, Rahali Younes3,4, Kartouti Abdeslam El1, Hafidi Youssef2, Laatiris Abdelkader3, Cherkaoui Nawal3 1Department of Pharmacy, Faculty of Medicine, Pharmacy and Dental Medicine of Fez, Sidi Mohamed Ben Abdellah University, Fez, Morocco 2Department of Pharmacy, Hassan II University Hospital of Fez, Morocco 3Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, Rabat, Morocco 4Ibn Sina University Hospital Center, Rabat, Morocco 5Faculty of Medicine and Pharmacy of Tangier, Abdelmalek Essaâdi University *Corresponding Author E-mail: chefchaouniali@gmail.com
Online Published on 07 February, 2024. Abstract Ibuprofen is a non-steroidal anti-inflammatory drug known for its remarkable therapeutic effects. It can be available in different forms among which are coated and sugar-coated tablets.The objective of this study was to compare the dissolution profile between these two forms. The study was conducted with 5 ibuprofen drugs: 3 generics and one reference drug based on coated tablets, and one drug containing the coated tablets.The parameters used to evaluate and compare the dissolution profiles were the similarity (f2) and difference (f1) factors.The results obtained showed similar dissolution profiles for the two types of coating, with a more significant release for the sugar-coated tabletsduring the first 30 minutes.Dissolution studies are important studies to establish equivalence between generic and brand name drugs, and also to predict the release of the AP. Top Keywords Ibuprofen, Dissolution, Coating, Sugar-coating. Top |