Fast Dissolving Oral Films: Formulation, Evaluation and Future aspects Bhattacharya Muniraj1, Sarkar Oindreela1, De Pintu K.1,2,* 1Department of Pharmaceutical Technology, JIS University, Kolkata, Pin Code: 700109 2JIS Institute of Pharmacy, Kalyani, Nadia, West Bengal, 741235 *Corresponding Author E-mail: pintu.de@jisuniversity.ac.in
Online Published on 07 February, 2024. Abstract Fast dissolving oral film (FDOF) are drug delivery systems of the new days having one of the highest patient compliance, safety and are economical than most other dosage forms. Hydrophilic polymers when used as a vehicle come in contact with water get hydrated and thus allow drug release. Hydrophilic polymers also show an adherence property post hydration. Thus the hydrating and adhering properties of hydrophilic polymers makes it most suitable for producing fast dissolving oral film. Fast dissolving oral films are made to be administered into the buccal cavity of humans as the buccal cavity if having saliva and saliva help to hydrate the films leading to drug release. The buccal cavity in humans has a very high amount of blood supply system thus aids in faster drug entrance into the blood circulation. The fast dissolving oral films are capable of initiating drug release within seconds, without chewing and drinking. The instant bioavailability achieved bypassing the fast pass metabolism also adds as a salient feature. Various compositions of different polymers lead to differences in drug release rate of the films. Polymers such as Hydroxy Propyl Methyl Cellulose; Poly Vinyl Alcohol; Ethyl Cellulose; Sodium Carboxymethyl Cellulose are some common hydrophilic polymers that are used to produce fast dissolving oral films. Solvent casting; semi solid casting; hot melt extrusion; solid dispersion extrusion are some common methods of production of fast dissolving oral films. Immediate onset of action in a shorter period with improved bioavailability marked fast dissolving oral film, a dosage form of choice. Top Keywords Fast dissolving, Oral film, Drug release, Bioavailability, Polymer. Top |