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Detection of the presence of blaTEM-1 gene for ESBL production among clinical strains of E. coli. Monalisa R., Dr. Gopinath Saveetha Dental College and Hospitals, No. 162, PH Road, Chennai-600077 Corresponding Author E-mail:
Online published on 2 March, 2017. Abstract Majority of ESBLs are derived from the amino acid substitutions of their parent enzymes TEM and SHV βlactamases, but there are several other types of acquired ESBLs found in Enterobacteriaceae. Among these ESBLs, TEM, SHV and CTX-M types of are of being major clinical concern and predominated in Gramnegative bacteria. In this study we have taken 20 clinical isolates of E. coli and were subjected to antibiotic sensitivity pattern followed by the detection of blaTEM-1gene by PCR. We have observed total resistance to cephalosporins followed by other group of drugs. 20% of our strains were found to have this gene. This indicates that apart from this gene there several other genes that encodes for ESBLs such as CTX-M, SHVetc may be the reason for showing the resistance. To rule out this more number of isolateshave to be included with a battery of other genes to be screened to get the actual outcome. Top Keywords E. coli, PCR, blaTEM-1gene. Top | |
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