Does a contraindication yield therapeutic activity? Dr Suseem S.R.1,*, Joseph Dhanish2 1Assistant Professor (Senior), School of Advanced Sciences, Department of Chemistry (SAS), VIT University, Vellore 2Department of Pharmaceutical Chemistry, SAS Vellore Institute of Technology, Vellore *Corresponding Author E-mail:
Online published on 2 March, 2017. Abstract Many drug molecules are contraindicated since it is harmful to the patient. These drug products act by producing any of the adverse drug reaction or side effects. This can happen not only with the drug molecule but also with dietary supplements that we call it as drug-food interaction. These interactions either enhance or decrease the drug levels in the body; thereby the drug may reach either the toxic stage or may not reach minimum concentration to produce the activity respectively. The principle of this contraindication is taken into consideration to enhance the bioavailability of lower bioavailable drug substances at a lower dose. The presystemic metabolism causes lower bioavailability of many drugs. With this type of drug molecules, the drug metabolising enzyme inhibitor substances are contraindicated. But the current study shows even though these are contraindicated; by administering the lower dose of the principle drug molecule and enzyme inhibitor together can enhance the bioavailability and can yield therapeutic activity without producing the toxic reaction. Top Keywords Bioenhancer, Enzyme inhibitor, Contraindication, Grapefruit juice, Drug Interaction. Top |