Fibrous Dysplasia-A Hallmark Fibro-Osseous Lesion of Bone: An Overview Khare Ankita1,*, Prasad Krishna Deo2, Sublok Karan3, Tak Jalaj4, Gupta Vineet4, Bali Ruchita5, Jan Iram1, Mittal Sachin6 1Post Graduate Student, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh 2Prof. & Head, Dept. of Oral Pathology & Microbiology, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh 3Post Graduate Student, Dept. of Oral & maxillofacial Surgery, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh 4Reader, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh 5Senior Lecturer, Dept. of Oral Pathology & Microbiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh 6Reader, Dept. of Oral Medicine & Radiology, Shree Bankey Bihari Dental College & Research Centre, Ghaziabad, Uttar Pradesh *Corresponding author: Dr. Ankita Khare Post Graduate Student, Dept. of Oral and Maxillofacial Pathology, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, Uttar Pradesh. Email: ankita.khare14@gmail.com
Online published on 7 March, 2016. Abstract Fibrous dysplasia is a common benign skeletal lesion that may involve one bone (monostotic) or multiple bones (polyostotic) and occurs throughout the skeleton with a predilection for the long bones, ribs, and craniofacial bones. The etiology of Fibrous dysplasia has been linked to the posygotic mutation in the GNAS 1 (guanine nucleotide-binding protein, alpha stimulating activity polypeptide 1) gene (20ql3.2–13.3) resulting in up-regulation of cAMP. It may be isolated to a single skeletal site or multiple sites and sometimes is associated with extraskeletal manifestations in the skin and/or endocrine organs (McCune-Albright syndrome). Top Keywords Fibrous Dysplasia, Monostotic, Polyostotic, GNAS1, cAMP. Top |