Accidental closantel toxicosis in camels Raval S.H.1,*, Parmar R.S.1, Chhatpar K.D.1, Patel J.G.1, Patel B.J.1, Joshi D.V.1 1Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University, Sardarkrushinagar, Gujarat, India *Corresponding author: e-mail: samirraval81@gmail.com
Abstract Closantel toxicity was suspected in 30 camels that received closantel at the dose rate of four to five times higher than the recommended dose. After 24 hours of closantel dosing, all 30 camels showed clinical signs like blindness, incoordination, ataxia, muscle tremors, depression and weakness. All affected camels received symptomatic treatment, although 14 camels died within 48 hours of intoxication. Remaining 16 camels died within a week period. Detailed postmortem examination revealed no appreciable gross lesions. Microscopically, severe lesions were noted in cerebrum, cerebellum, optic nerve and retina, while, moderate to mild lesions were noted in liver, kidney and lungs. White matter and gray matter of cerebellum and cerebrum showed marked spongy degeneration. Lesions were more severe in white matter compared to gray matter. Retina was completely effaced by clear vacuoles/cyst like spaces found diffusely above pigmented/choroid layer. Cornea showed edema and ulcer formation. Most hepatocytes showed variable sized, clear, one or occasionally more than one vacuoles in cytoplasm. Kidney showed lesions like interstitial edema, tubular degeneration and compression of glomeruli. In present study, cerebrum, cerebellum, optic nerve and retina were prime target of closantel toxicity. Top Keywords Camel, Closantel toxicity, Optic neuropathy, Retinal degeneration, Spongy degeneration. Top |