Toxicity of fenvalerate on immune system and immuno-modulatory effects of Withania somnifera (Ashwagandha) in cockerels Tikore P.V.3, Rathod P.R.3,*, Ingole R.S.3, Khodke M.V.1,3, Khose K.K.2,3 3Department of Veterinary Pathology, Post Graduate Institute of Veterinary and Animal Sciences (MAFSU, Nagpur), Akola-444104, Maharashtra, India 1Department of Veterinary Biochemistry, Post Graduate Institute of Veterinary and Animal Sciences (MAFSU, Nagpur), Akola-444104, Maharashtra, India 2Department of Poultry Science, Post Graduate Institute of Veterinary and Animal Sciences (MAFSU, Nagpur), Akola-444104, Maharashtra, India *Address for Correspondence P.R. Rathod, Department of Veterinary Pathology, Post Graduate Institute of Veterinary and Animal Sciences (MAFSU, Nagpur), Akola-444104, Maharashtra, India, e-mail: pravintoo@gmail.com
Abstract The effect of supplementation of Withania somnifera root powder on the immune-modulatory response in cockerels with induced sub-acute fenvalerate toxicity was investigated. After acclimatization for a period of one week, day-old 80 cockerels were randomly divided into four equal groups comprising 20 birds in each. Group T1 (control), group T2, was treated with fenvalerate @ 300 mg/kg of feed, group T3, was treated with Withania somnifera @ 200 mg/kg of feed and group T4, was given fenvalerate @ 300 mg/kg of feed with Withania somnifera @ 200 mg/kg of feed for four weeks and withdrawal of treatment for seven days. Haemagglutination inhibition (HI) titer against Newcastle Disease virus (NDV) in fenvalerate treated group was found to be significantly (Pd”0.05) decreased. T4 group showedan immune-modulatory activity of Withania somnifera during fenvalerate toxicity at 5th week, while immune response of T2 group was not significantly different at 6th week, which indicated enhanced immune response of this group. Histologically, spleen, bursa of Fabricius and thymus showed depletion of lymphocytes and focal necrosis probably due to immunotoxic effects of fenvalerate. Thyroid gland exhibited minimum amount of colloid and vacuolization in the lining epithelium of the follicles. Amelioration of these lesions were seen in the T4 group due to the protective effect of Withania somnifera. Birds of T2 group, examined after having fed for 6 weeks, showed mild lesions indicating recovery and in T4 group showed a moderate recovery. How to cite this article: Tikore, P.V., Rathod, P.R., Ingole, R.S., Khodke, M.V. and Khose, K.K. (2019). Toxicity of fenvalerate on immune system and immuno-modulatory effects of Withaniaso-mnifera (Ashwagandha) in cockerels. Indian J.Vet. Pathol., 43(2): 115–119. Top Keywords Fenvalerate, Histopathology, Withania somnifera. Top |