Year : 2018, Volume : 42, Issue : 1
First page : ( 43) Last page : ( 50)
Print ISSN : 0250-4758. Online ISSN : 0973-970X. Published online : 2018 March 1.
Article DOI : 10.5958/0973-970X.2018.00008.1

Ameliorative effect of Centella asiatica on induced arsenic toxicity in Wistar rats: Pathomorphological study

Goyal A.¹, Singh N.D.¹, Banga H.S.¹

¹Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141004, Punjab, India

*Corresponding author: e-mail: drndsingh@gmail.com

Received:  1  December,  2017; Accepted:  26  March,  2018.

Abstract

The present study was undertaken to study the ameliorative effect of Centella asiatica in arsenic induced toxicity. Ninety healthy Wistar rats were randomly divided into six groups of 15 animals each (I: Control; II: Sodium arsenite @ 2.5ppm in drinking water; III: Sodium arsenite@ 2.5 ppm+ C.asiatica@ 200ppm in feed; IV: C.asiatica@ 200ppm; V: Sodium arsenite@ 5.00ppm; VI: Sodium arsenite@ 5 ppm+ C.asiatica@ 200ppm in feed)and fed the above dose regimen for 60 days. Results showed testes, brain, liver and kidneysas the main target organs of arsenic toxicity with decreased spermatogenic activity in testes; whereas no change was observed in female reproductive organs, indicating that arsenic will be more harmful for male reproductive systems. It was concluded that C.asiatica when given at the rate of 200ppm partially ameliorated the toxic effect of arsenic @ 2.5 ppm, however, it did not able to ameliorate when arsenic was given at a higher dose of 5 ppm. Moreover, C. asiatica did not cause any toxic effect on rats when fed at 200ppm suggesting that it is very safe and helpful in its ameliorative action.

Top

Keywords

Arsenic, Centella asiatica, Histopathology, Immunohistochemistry Wistarrats.

Top