Clinicopathology of sodium bicarbonate induced gout in broiler chicken model Ali Rayeesa1, Kamil S.A.1,*, Amin U.1, Mir M.S.1, Shah A.1, Kashani B.1, Dar T.A.1, Shah S.A.1, Qureshi Sabia1 1Division of Veterinary Pathology, Faculty of Veterinary Sciences & Animal Husbandry, Sher-e-Kashmir University of Agricultural Science & Technology (SKUAST-K), Srinagar-190006, Jammu and Kashmir, India *Corresponding author: e-mail: kamilshoaib@gmail.com
Abstract Clinicopathological changes due to sodium bicarbonate induced gout in broiler chickens were investigated. Seven-day old broiler chickens were randomly divided into 3 groups (n=12). Group I served as vehicle-treated control, Group II and III were given sodium bicarbonate @ 2.5% and 5% respectively, in drinking water. Clinical signs developed progressively from 4th day of the exposure. 25% and 58.33% mortality was recorded in Group II and III, respectively. Deposits of chalky white urates were prominently seen in kidneys, liver, heart and proventriculus. Histopathological lesions included severe degeneration and necrosis of renal tubules and heterophil infiltrations; large focal areas of coagulative necrosis, congestion of central vein, fatty change and periportal and paraportal lymphoid infiltrations in liver; degeneration of cardiac muscles; and congestion and serous exudate in parabronchi of lungs. Thymus revealed severe congestion, degeneration and necrosis of lymphoid tissue with serofibrinous exudate. Masson's Trichrome stain revealed fibrosis in kidneys, liver, heart and lung tissues, whereas De Galantha's stain showed urate deposits as tophi or amorphous material. Top Keywords Chicken, DeGalantha's stain, Gout, Masson's trichrome, Sodium bicarbonate, Thymus, Urates. Top |