Oxovanadium (IV) complexes of α-Amino acid schiff bases and 2,2′-Bipyridine ligands: Synthesis, characterization and investigation of their biological potency Islam Md. Tariqul, Bitu Md. Nur Amin, Ali Md. Asraf, Hossen Md. Faruk, Kudrat Md. E-Zahan* Department of Chemistry, University of Rajshahi, Rajshahi - 6205, Bangladesh *Corresponding Author E-mail: kudrat.chem@ru.ac.bd
Online Published on 31 August, 2024. Abstract Five new oxovanadium(IV) complexes of the type [VO(L)(bpy)], [where L= 3-hydroxybenzaldehyde-α-alanine (hb-ala), 3-hydroxybenzaldehyde-DL-phenylalanine (hb-pheala), 3-hydroxybenzaldehyde-leucine (hb-leu), 3- hydroxybenzaldehyde-glycine (hb-gly) and 3-hydroxybenzaldehyde-DL-methionine (hb-met) and bpy = 2,2´- bipyridine] have been synthesized and characterized by some physicochemical properties, molar conductance, magnetic susceptibilities measurements, elemental analysis, UV-Visible and FTIR and ESI-MS spectral studies. The molar conductance values showed that the complexes are non-electrolytic in nature. The magnetic moment values of the complexes are in accordance with the d1 electronic configuration of the VIVO2+ moiety and indicates the paramagnetic nature of the complexes. IR spectral data indicates the coordination of tridentate amino acid Schiff base ligands to the vanadyl (VO2+) ion through O, N, O-donor. ESI-MS spectral studies supports the proposed structure of the complexes. The magnetic moment value coupled with electronic spectral data suggested the distorted octahedral geometry of the complexes. All the complexes were screened for their antibacterial activity against three human pathogenic bacteria- Escherichia coli, Staphylococcus aureus and Bacillus cereus with Kanamycin (K-30) standard. The result shows that all the complexes possess to have moderate to strong potential antibacterial activity against all the tested pathogens. Top Keywords Oxovanadium (IV) complexes, α-Amino acidsSchiff base, 2,2´-bipyridine, Antibacterial activity. Top |