Role of Platelet Rich Plasma With Beta Tricalcium Phosphate as Graft In Oral Cystic Defects” Amir Abu1,*, Iqbal Ali2, Shankar Natu Subodh3 1Assistant Professor, Faculty of Dental Sciences, Integral Institute of MedicalSciences & Research Integral University, Lucknow 2Professor & Head, Faculty of Dental Sciences, Integral Institute of MedicalSciences & Research Integral University, Lucknow 3Assistant Lecturer, Faculty of Dental Sciences, Integral Institute of MedicalSciences & Research Integral University, Lucknow *Address for Correspondence: -Dr. Amir Abu, Assistant Professor, Faculty of Dental Sciences Integral Institute of MedicalSciences & Research Integral University, Lucknow, E-mail: ansari.abuaamir@gmail.com
Online published on 18 May, 2016. Abstract Introduction Platelet-rich plasma (PRP) is defined as the platelet containing supernatant of centrifuged anticoagulated blood and is inherently safe and is free from transmissible diseases such as HIV and Hepatitis. PRP is rich in native growth factors in their biological determined ratios thereby playing an important role in bone regeneratrion. Aims and Objectives Aims and objectives of this study were to analyze the role of PRP with bone graft (Tricalcium phosphate) in wound healing of maxillofacial defects and to compare the same with bone graft (Tricalcium phosphate) without PRP. Material & Method A total of 30 subjects with maxillofacial bony defects were enrolled in the study. They were randomly divided into two equal groups comprising of 15 patients each. Study group received PRP mixed with equal volume of beta tricalcium phosphate graft, whereas the control group received only beta tricalcium phosphate graft. Platelet rich plasma was prepared by withdrawing 10 ml of patients blood followed by centrifugation for 10 minutes at 1300 rpm resulting in separation of whole blood into a lower red blood cell (RBC) region and upper straw-colored plasma region. Following aspiration of upper straw colored plasma layer, top part of the RBC layer along with Buffy coat with micro pipette, it was transferred into another container (sterile plain vacutainer) and again centrifuged for 10 minutes at 2000 rpm to achieve PRP The statistical analysis was done using SPSS (Statistical Package for Social Sciences) Version 15.0 statistical Analysis Software. Result In the study group there was early relief from pain, swelling, and dense texture of trabaecular pattern and radiological rim formation indicative of bone formation was noticed. Significant reduction in pain and swelling was seen from first week itself in both the groups. Conclusion On the basis of low incidence of pain, swelling, infection and early bone formation and healing in study group as compared to control group, beta-Tricalcium phosphate along with PRP seems to be a promising method for management of bony jaw defects. Top Keywords Platelet Rich Plasma, Bone Graft, Beta Tricalcium Phosphate, Growth Factors, Maxillofacial Defects. Top |