Comparative study of ondansetron, granisetron and ramosetron in prevention of post operative nausea and vomiting Dr Mattoo Juhi1, Dr Thosani Rajesh2 1Assistant Professor, Cardiac Anesthesia, U N Mehta Institute of Cardiology and Research Centre 2Associate Professor, Cardiac Anesthesia, U N Mehta Institute Of Cardiology And Research Centre Online published on 17 February, 2017. Abstract Introduction Nausea and vomiting have been associated with the use of general anesthetics for cardiac surgical procedures, with nausea, retching & vomiting as the most common postoperative complaints. The aim of the study is to compare the antiemetic effects of intravenous ondansetron, granisetron & ramosetron in a randomized double blind controlled manner for prevention of nausea and vomiting in early postoperative period in patients undergoing cardiac surgery. Material & Methods Ninety patients undergoing cardiac surgery were randomly allocated into three equal groups, each receiving ondansetron, granisetron and ramosetron via intravenous route, before induction of anaesthesia. Anesthetic procedure was common to all patients. Emetic episodes in early postoperative period (first three hours) and delayed (upto 24 hours) were recorded and compared in different study groups. Conclusion Based on this study it can be concluded that in early postoperative period (first three hours) the three drugs ondansetron, granisetron and ramosetron are comparable to each other. If we consider the delayed postoperative period (upto 24 hours) ramosetron appears better than ondansetron. Effects of ramosetron and granisetron are comparable to each other. Top Keywords Post operative nausea & vomiting (PONV), cardiac surgery, ondansetron, granisetron and ramosetron. Top |