Increased total antioxidant capacity in renal tissue of female BWF1 mice infected with Plasmodium chabaudi Maksoud Mostafa A. Abdel1,2,*, Abdel-Ghaffar Fathy A.2, El-Amir Azza2, Badr Gamal3, Al-Quraishy Saleh1 1Zoology Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia 2Zoology Department Faculty of Science, Cairo University, Cairo, 61616, Egypt 3Laboratory of Immunology & Molecular Physiology, Zoology Department Faculty of Science, Assiut University, Assiut, 71516, Egypt *Corresponding author's e-mail: harrany@gmail.com
Online published on 16 November, 2019. Abstract We have investigated the effect of malaria infection on the urine biochemistry and the renal and hepatic levels of total antioxidant capacity (TAC) in female BWF1 lupus mice. A total of 30 female BWF1 lupus mice were divided into three groups as follows: group (I) control group; group (II) lupus mice infected with live Plasmodium. chabaudi; group (III) lupus mice infected with irradiated P. chabaudi. Mice were killed at day 14 post-infection and plasma samples were collected. live P. chabaudi infection was associated with decreased level of glucose in urine (glucosuria), increased urinary level of both ketones (ketonuria) and blood (hematuria). Additionally, live P. chabaudi infection was associated with increased level of TAC in the renal tissue with decreased level of TAC in the hepatic tissue of infected mice. In conclusion, P. chabaudi infectionhas adirect effecton the urine biochemistry and the renal and hepatic levels of TAC in BWF1 mice. Top Keywords Glucosuria, Haematuria, Ketonuria, Lupus, Malaria, Total antioxidant capacity. Top |