The predictive power of microalbuminuria in diagnosing diabetic retinopathy in adults with Type II diabetes mellitus Ashrit Pallavi1, Kumar Arun1,*, Reddy Gundumalla Pradeep2, Kalasker Vishal3, Bhat Harish1 1Assistant Professor, Dept. of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India 2Tutor, Dept. of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India 3Profesor, Dept. of Biochemistry, Navodaya Medical College, Raichur, Karnataka, India *Corresponding Author: Email: arunmd26@gmail.com
Online published on 2 January, 2019. Abstract Introduction Diabetes Mellitus is one of the most common metabolic disorders, resulting in hyperglycemia and is associated with micro and macro vascular complications. Diabetic retinopathy (DR) is a widely accepted cause of blindness in adults. The duration of diabetes, glycemic control and microalbuminuria (MA) have been implicated in the onset and progression of DR. Materials and Methods The aim of our study is to correlate FBS, PPBS, HbA1c and microalbuminuria with diabetic retinopathy and to find out MA as the predictor of DR in T2DM patients. Our study included, 50 T2DM patients with DR, 50 T2DM patients without DR and 50 controls of both sex in the age group of 40–60 years. Fasting blood sugar (FBS) and post prandial blood sugar (PPBS) were estimated by Glucose Oxidase method, glycated hemoglobin (HbA1c) by Ion Exchange Resin Method and urine samples were assayed for Microalbumin by Immunoturbidimetric assay and DR was diagnosed using Fundoscopy. Results In our study, levels of urinary microalbumin, FBS, PPBS and HbA1c in T2DM patients with DR is increased than T2DM patients without DR than the control group, which is highly significant (p <0.001). HbA1c and Microalbuminuria in T2DM are positively correlated. All the parameters (FBS, PPBS, HbA1c and microalbuminuria) in group A cases are positively correlated with grades of Diabetic Retinopathy. Conclusion Microalbuminuria and diabetic retinopathy are closely associated in T2DM patients and is a reliable marker which can predict the risk for the development of DR. All patients with MA should undergo regular retinal evaluation. Top Keywords Type II diabetes mellitus (T2DM), Microalbuminuria (MA), Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS), Glycated Hemoglobin (HbA1c), Diabetic Retinopathy (DR). Top |