Level of IMA in newly diagnosed untreated hypothyroid subjects diagnosed during routine screening at Tertiary Care Hospital in North India Agrawal Poonam1,*, Verma Niket2, Binita3, Sethi Sumita4, Pratima5 1Associate Professor, Dept. of Biochemistry, Army College of Medical Sciences, Delhi Cantt, New Delhi, Delhi 2Assistant Professor, Dept. of Medicine, Army College of Medical Sciences, Delhi Cantt, New Delhi, Delhi 3Associate Professor, Dept. of Biochemistry, Maulana Azad Medical College, New Delhi, Delhi 4Associate Professor, Dept of Opthalmology, BPS Government Medical College, Sonipat, Haryana 5Professor & HOD, Dept. of Pathology, Dr Baba Sahib Ambedkar Medical College and Hospital, New Delhi, Delhi, India *Corresponding Author: Email: drpoonam24agrawal@yahoo.com
Online published on 2 January, 2019. Abstract Introdcution Aim of this study was to assess the level of ischemia modified albumin(IMA) in newly diagnosed untreated hypothyroid subjects. Materials and Methods Serum IMA assessment was done by Barr et al method 30 newly diagnosed patients of hypothyroidism For the control group 50 normal healthy euthyroid adults were selected. TSH was done by one-step sandwich ELISA, and fT3, fT4 was done by one-step competitive ELISA method. Data were presented as mean ± standard deviation (SD). Results Serum IMA was not found to be statistically different between hypothyroid and euthyroid control group. Conclusion Contrary to the findings of majority of studies done on this subject, our study has not shown any significant elevation of IMA in hypothyroid subjects as compared to euthyroid subjects. IMA level in subjects of hypothyroidism has been a controversial issue since long. Assessment of cIMA should be done in association with other oxidative stress marker, and their correlation if any should be studied in a large cohort. Top Keywords IMA, cIMA, Hypothyroid, Oxidative stress. Top |