Study of Bone Marrow in Metastatic Tumors in Northern India Garg Prem K1, Deshmukh Ajoy2, Mahabole Kiran G3, Deshmukh Geeta4, Madan Jyotsna5 1Associate Professor, Department of Pathology, Mayo Institute of Medical Sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, India 2Associate Professor, Department of Medicine, School of Medical Science and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, India 3Professor and HOD, Department of Pathology, Dr. B. R. Sur Homeopathic Medical College and Hospital and Research center, New Delhi, India 4Professor, Department of Pathology, School of Medical Science and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, India 5Professor, Department of Pathology, Santosh Medical College, Ghaziabad, Uttar Pradesh, India Online published on 24 April, 2013. Abstract Introduction Bone marrow in addition to being the site of origin of numerous primary hematological malignancies, is also commonly involved by Metastatic tumors. Those diagnosed primary tumors, whose metastasis was suspected clinically, radio logically and by other biochemistry investigations, were confirmed by bone marrow aspiration and biopsy examination. Objectives The present study (2006 - 2012) has been aimed to report our bone marrow aspiration (BMA) and bone marrow biopsy (BMB) experience with seventy eight (78) patients of Metastatic tumors from North India and compare the results of bone marrow aspirations with bone marrow biopsy. Material and Methods In our study we have included cases of Carcinoma of Breast, Prostate, Lung, Kidney, Urinary bladder, GIT, Thyroid, Round cell tumors and indeterminate tumors (suspected secondary in unknown primary). In each case bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined. Results Out of seventy eight (78) cases of Metastatic tumors, there were maximum cases of breast carcinoma, twenty four cases (30.76%) followed by round cell tumors and indeterminate tumors, twelve cases each (15.38%), and prostate carcinoma ten cases (12.82%). There were six cases of lung carcinoma (07.69%) and four cases of each from kidney carcinoma, urinary bladder carcinoma and GIT carcinoma (05.12%). There were only two cases of thyroid carcinoma (02.56%). Lymphomas were excluded from the study. Conclusion The study showed slightly male predominance and was most common in the two extremes of the life (. 0–10 years and 41–70 years.) In this study bone marrow biopsy was found to be more informative than aspiration. The minimum criterion for diagnosis of metastasis was at least one cluster of tumor cells in the bone marrow aspiration and biopsy. Bone marrow involvement indicated poor prognosis in Metastatic tumors and there was no clearing of metastasis in the bone marrow after chemotherapy and radiotherapy. There were virtually no complications to aspiration and biopsy of the bone marrow even in cases of thrombocytopenia. Top Keywords Bone Marrow Aspiration (BMA), Bone Marrow Biopsy (BMB), Metastatic Tumors. Top |