Autoimmune Thyroid Dysfunction and Meniere's Disease Muzaffar Rahil*, Postgraduate Resident, Mattoo Owais, Postgraduate Resident, Mir Anees, Senior Resident, Ahmad Rauf, Professor ENT Head & Neck Surgery, Govt. Medical College Srinagar, J&K *Corresponding author: Rahil Muzaffar, C/o. Dr. Muzaffar Ali, R/o. Hilal Abad Colony,Sector 1, Qamarwari, Srinagar, J&K, India-190010, Email-id: rahil_muzaffar@yahoo.com, Mobile No.+919858321825
Online published on 7 October, 2013. Abstract Title Autoimmune thyroid dysfunction and Meniere's disease. Study Design Prospective Case-Control study. Method This study was conducted in the Department of Otorhinolaryngology, Head & Neck Surgery, S.M.H.S Hospital, an associated hospital of Government Medical College Srinagar, for a period of 22 months w.e.f January 2011 to October 2012. In this study, we evaluated the association between thyroid autoimmunity and Meniere's disease. 35 Meniere's disease patients were enrolled in this study and two groups as controls: group A, 20 subjects suffering from acute unilateral peripheral vestibulopathy of non-Meniere origin; and group B, 30 healthy volunteers. All subjects were submitted to assessment of cochlear-vestibular function and analysis of standard thyroid function test, anti-TSH receptor antibody (TR-Ab), anti-thyroperoxidase antibody (TPO-Ab) and anti-thyroglobulin antibody (Tg-Ab). Results The prevalence of autoimmune thyroiditis in Meniere's disease patients was higher (P <0·01) when compared to control groups. Conclusion Our data demonstrate a significant association between Meniere's disease and thyroid autoimmunity, which suggest that an autoimmune factor may be involved in the aetiopathogenesis of this disease. Top Keywords Meniere, Autoimmune, Thyroglobulin, Thyroid-peroxidase. Top |