Porphyromonas Gingivalis fimA Genotype in Chronic Periodontitis Mahalakshmi Krishnan* Professor and Head, Dept of Microbiology/Research Lab for Oral-Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Velachery-Tambaram Road, Chennai, Tamil Nadu, India *Corresponding Author: Krishnan Mahalakshmi. Professor and Head, Dept of Microbiology/Research Lab for Oral-Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Velachery-Tambaram Road, Chennai-600100, Tamil Nadu, India, Contact No.: (M) 9444184403, e-mail: kmagvenkat@gmail.com
Online published on 31 March, 2020. Abstract Background Periodontitisis an inflammation of the periodontium with varied etiologyleading to loss of periodontal supporting tissues of the teeth including the periodontal ligament and alveolar bone. Periodontitis progresses as a result of the direct effects of bacterial virulence factors on host tissues, as well as self-damaging host responses to the colonizing bacteria. Method PCR was performed on the sub gingival plaque samples positive for P.gingivalis from chronic periodontitis patients (n=103) and healthy subjects (n=22) Chi-square test was performed to calculate the statistical significance. Result P.gingivalis type II fimA genotype was positivein 50.5% and 13.60% among patients with chronic periodontitis and health respectively. positivity for P.gingivalistype II fimA genotype. Statistical significance was observed for the prevalence of P.gingivalistype II fimA genotype (p=0.03) in chronic periodontitis group. Conclusion The significant presence of P. gingivalistype II fimA genotypein chronic periodontitis compared to health suggests their role in the etiology of chronic periodontitis. Top Keywords Periodontitis, Inflammation, Plaque. Top |