Improved WOMAC Score Following Treatment with Nanoparticle Phyllanthus Amarus Phonophoresis Gel for Knee Osteoarthritis Pinkaew Decha1,*, Kiattisin Kanokwan2, Wonglangka Khanittha1, Awoot Pisittawoot3 1Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand 2Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand 3Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand *Corresponding Author: Decha Pinkaew, Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, e-mail: decha303@gmail.com
Online published on 4 April, 2020. Abstract Objective The aim of this study is to compare the effects of phonophoresis of nanoparticle Phyllanthus amarus phonophoresis gel (PP) and ultrasound therapy (US) in patients with osteoarthritis of knee (OA). Method OA knee patients (n=40) who had symptomatic knee pain were randomly allocated into 2 groups. There are US group (ultrasound group) and PP group (Phyllanthus amarus gel phonopheresis group)(20 in each group) were treated with an ultrasound program by using continuous mode, 1.0 W/cm2, 10 minutes per session, once daily and10 sessions. The nanoparticle Phyllanthus amarus gel was used in the PP group, while the US group was use the nondrug coupling gel. Pain and function assessment were measured by the visual analog scale (VAS) and the Western Ontario and McMaster Universities O-osteoarthritis Index (WOMAC), respectively. Moreover, the range of motion was used to measureby goniometers. Three primary outcomes were investigated before and after treatment 10 sessions. Results The VAS and total WOMAC scores were significantly increasedpost-treatment in both groups (P < 0.001). The PP group showed more significant improve VAS and total WOMAC scores than the US group (P<.001). However, ROM was not significant in both groups to compare to baseline. Conclusion The nanoparticle Phyllanthus amarus phonophoresis gelwas significantly reduced pain and improve knee functioning. Itis suggested as a new, effective method for treatment OA knee for relieving pain and improving function. Top Keywords Knee osteoarthritis, Phyllanthus amarus, phonophoresis, ultrasound therapy, visual analog scale. Top |