Role of Oxidative Stress in Development of Nephropathy in Diabetic Patients Julius A.1, Renugadevi K.2, Bhuminathan S.3, Jayesh S. Raghavendra3, Shobakishore4 1Professor and Head, Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai 2Research Scholar in Bharathiar University, Coimbatore, Asst. Professor, Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College, Venkatsennagar, Chennai 3Professor, Department of Prosthodontics, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai 4Research Scholar Bharath Institute of Higher Education and Research, (Bharath University), Associate Professor, Department of Pathology, Sree Balaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai Online published on 4 April, 2020. Abstract Diabetes Nephropathy is a major microvascular complication of Diabetes Mellitus and the most common cause of End Stage Renal Disease (ESRD) worldwide. Hyperglycemia, a well recognized pathogentic factor of long term complications of Diabetes Mellitus, generates ROS. This attenuates antioxidative mechanisms through glycation of the scavenging enzymes. Excess amount of ROS modulate activation of protein kinaseC, mitogin activated protien kinares and various cytokines and transcription factors which eventually cause increased expression of extracellular matrix (ECM) genes with progression of fibrosis and end stage renal disease. Therefore, this study was carried out to investigate oxidant and antioxidant status in Diabetic patients for manifesting the progression to diabetic nephropathy. Top Keywords Diabetic Nephropathy, Hyperglycemia, Reactive Oxygem Species, Extracellular Matrix, Oxidative Stress. Top |