Uromodulin a Screening Marker of Nephrolithiasis in Essential Hypertension Julius A.1, Renugadevi K.2, Bhuminathan S.3, RaghavendraJayesh S.3, Shobakishore4,5 1Professor and Head, Department of Biochemistry, Sree Balaji Dental College and Hospital, Bharath Institute of HigherEducation and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai 2Research Scholar in Bharathiar University, Coimbatorem, Asst. Professor, Department of Biochemistry, Prince Shrivenkateshwara Arts and Science College, Venkatsennagar, Chennai 3Professor, Department of Prosthodontics, SreeBalaji Dental College and Hospital, Bharath Instituteof HigherEducation and Research, (Bharath University), Narayanapuram, Pallikaranai, Chennai 4Research Scholar, Bharath Institute of Higher Education and Research, (Bharath University) 5Associate Professor, Department of Pathology, SreeBalaji Dental College and Hospital, Narayanapuram, Pallikaranai, Chennai Online published on 4 April, 2020. Abstract Tamm Horsfall Protein or Uromodulin is the most abundant urinary glycoprotein that has a protective function in the bladder mucosal layer. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Using ELISA, the autoantibody level of Tamm Horsfall Protein in serum was determined in Hypertensive Patients and control subjects. A significant percentage of hypertensive subjectshave a greater risk of renal stone formation, with high autoantibodies level to Tamm Horsfall Protein in serum when compared to control subjects. Hence THP acts as a potential biomarker for nephrolithiasis in Hypertensive patients. Top Keywords Tamm Horsfall Protein Hypertension ELISA Autoantibody Nephrolithiasis. Top |